Hierarchical microstructural tissue growth of the gray and white matter of human visual cortex during the first year of life
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View abstract on PubMed
Summary
This summary is machine-generated.Human brain development shows visual system tissues grow rapidly in the first year. Microstructure develops hierarchically, with early visual areas maturing slower but earlier than higher-level areas.
Area Of Science
- Neuroscience
- Developmental Biology
- Medical Imaging
Background
- Gray and white matter microstructure development is crucial for sensory and cognitive functions.
- Understanding early visual system development in infants is limited.
- Quantitative MRI offers insights into tissue microstructural changes.
Purpose Of The Study
- To measure the longitudinal development of gray and white matter microstructure in the human visual system during the first year of life.
- To investigate microstructural development across dorsal, lateral, and ventral visual processing streams.
- To establish a link between microstructural development and functional maturation of the visual cortex.
Main Methods
- Utilized quantitative magnetic resonance imaging (MRI) to measure tissue relaxation rate (R1).
- Analyzed R1 in gray and white matter across three visual processing streams in 85 infant sessions.
- Tracked microstructural development longitudinally from birth to 12 months.
Main Results
- R1 increased in all visual gray and white matter regions, indicating postnatal microstructural growth.
- Growth rates varied, with faster development between 0-6 months and in white matter compared to gray matter.
- A hierarchical development pattern was observed, with early visual areas maturing earlier but developing slower than higher-level areas.
Conclusions
- This study provides the first comprehensive measurement of infant visual system microstructural growth.
- Findings suggest a hierarchical pattern of microstructural development across visual processing streams.
- Proposes a new hypothesis linking visual cortex functional development to hierarchical microstructural maturation.
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