Related Experiment Video

Updated: Jan 22, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.3K

Outcomes of Bypass Surgery in Patients with Moyamoya Syndrome Secondary To Sickle Cell Disease: a Multicenter Study

Basel Musmar1, Joanna M Roy1, Hammam Abdalrazeq2

  • 1Department of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Translational Stroke Research
|January 21, 2026
PubMed
Abstract

Insights

Surgical revascularization for moyamoya syndrome (MMS) in sickle cell disease (SCD) patients is safe and effective. Outcomes are comparable to non-SCD patients, supporting bypass surgery for this high-risk group.

Area of Science:

  • Neurology
  • Vascular Surgery
  • Hematology

Background:

  • Moyamoya syndrome (MMS) with sickle cell disease (SCD) presents a severe vasculopathy with high stroke risk.
  • Cerebral revascularization is considered, but perioperative safety and long-term outcomes are concerns in SCD patients.

Purpose of the Study:

  • To evaluate the safety and efficacy of surgical revascularization in patients with MMS associated with SCD.
  • To compare perioperative and long-term outcomes between SCD-MMS and moyamoya disease (MMD) patients.

Main Methods:

  • A multicenter, retrospective cohort study of 553 MMS patients undergoing surgical revascularization.
  • Patients were stratified by SCD status (SCD-MMS vs. MMD).
  • Primary outcomes included perioperative stroke, complications, and functional status; secondary outcomes included length of stay and follow-up stroke.

Main Results:

  • No significant differences in perioperative stroke, symptomatic stroke, or complications between SCD-MMS and MMD groups.
  • Functional outcomes at discharge were comparable (mRS 0-1).
  • SCD-MMS patients experienced a longer hospital stay.

Conclusions:

  • Surgical revascularization for MMS in SCD patients does not increase procedural risk.
  • Outcomes are comparable to non-SCD patients, supporting bypass surgery as a viable treatment.
  • This approach is a beneficial option for this high-risk population.
Keywords:
Bypass, moyamoyaCohortMulticenterRevascularizationSickle cell

More Related Videos

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients03:47

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

619
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.3K

Related Concept Videos

Secondary Active Transport01:55

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
137.3K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
222
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.2K
Secondary Healthcare System01:11

Secondary Healthcare System

Secondary healthcare is offered by a specialist, generally in hospitals or clinics for patients referred by primary healthcare providers. It occurs when a person has an illness or injury that requires specific medical care. Secondary care is often referred to as acute care. Secondary care can range from uncomplicated care to repair a minor laceration or treat a strep throat infection to more complicated emergent care, such as treating a head injury sustained in an automobile accident. Whatever...
2.0K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.3K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
106.8K