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Updated: Jan 22, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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Contrasting Features of Papillary and Chromophobe Renal Cell Carcinoma Revealed by Whole-Genome Sequencing

Richard Culliford1, Charlie Mills1, Daniel Chubb1

  • 1Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.

Molecular Cancer Research : MCR
|January 21, 2026
PubMed

Insights

This study reveals distinct genetic features of papillary renal cell cancer (pRCC) and chromophobe renal cell cancer (ChRCC). Understanding these genomic alterations can guide precision oncology and clinical trials for these rare kidney cancer subtypes.

Area of Science:

  • Genomics
  • Oncology
  • Cancer Research

Background:

  • Precision oncology relies on identifying cancer drivers.
  • Renal cell cancer (RCC) research has focused on clear cell subtypes, with limited analysis of papillary RCC (pRCC) and chromophobe RCC (ChRCC).

Purpose of the Study:

  • To comprehensively analyze the genomic landscape of pRCC and ChRCC.
  • To correlate genomic alterations with histological subtypes and immune escape mechanisms in RCC.

Main Methods:

  • Whole genome sequencing of 164 tumor-normal pairs from the Genomics England 100,000 Genomes Project.
  • Analysis of copy number alterations, structural variations, mutational signatures, intra-tumor heterogeneity, and extrachromosomal DNA.

Main Results:

  • Detailed genomic maps for pRCC and ChRCC were generated.
  • Correlations between genomic alterations, histological diversification, and immune escape were established.
  • Distinctive genetic profiles characterizing pRCC and ChRCC were identified.

Conclusions:

  • The study highlights the unique genetics of pRCC and ChRCC.
  • This genomic information has the potential to inform patient treatment strategies and clinical trial design for these RCC subtypes.

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