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Light-Mediated g-C3N4-Catalyzed Anti-Markovnikov Hydroarylation of Enamides: Direct Access to β-Arylethylamine with
Yu Wang1, Qingqiang Tian1, Bingrui Liu1,2
1Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri-food Quality Safety, Anhui Agricultural University, Hefei 230036, China.
Abstract:
Hydroarylation is an efficient strategy for the conversion of unsaturated precursors into functional structural motifs. Herein, with reusable g-C3N4 as the photocatalyst, we disclose a photocatalytic anti-Markovnikov hydroarylation to synthesize β-arylethylamines. The combination of g-C3N4 and thiol facilitates diverse aryl radical addition reactions from aryl(hetero) halide substrates. Scalability and recyclability studies demonstrate the robust efficiency and stability of g-C3N4, underscoring its industrial potential. Notably, selected derivatives exhibit potent nematicidal activity, representing a promising class of agrochemical candidates.
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