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Radiographically-Measured Sarcopenia Predicts Hospitalization in Patients With Crohn's Disease.

Aman S Bali¹, Walaa G El Sheikh², Ahmed Ouni³

¹Section of Gastroenterology and Hepatology, Baylor College of Medicine.

Journal of Clinical Gastroenterology

|January 21, 2026

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This summary is machine-generated.

Sarcopenia (SP) in Crohn's disease (CD) patients is linked to higher hospitalization rates. Low skeletal muscle index (SMI) is a significant predictor of poor outcomes in CD patients.

Area of Science:

Gastroenterology
Radiology
Body Composition Analysis

Background:

Sarcopenia (SP) is an emerging prognostic indicator in Crohn's disease (CD).
Radiographic assessment of SP can provide objective measures for disease management.
Understanding the link between SP and CD outcomes is crucial for patient care.

Purpose of the Study:

To establish a CD-specific definition of sarcopenia using radiographic measurements.
To investigate the association between sarcopenia and CD-related outcomes, including hospitalization.
To evaluate the utility of skeletal muscle index (SMI) as a prognostic marker in CD.

Main Methods:

Retrospective analysis of adult CD patients undergoing CT scans.
Sarcopenia assessed using skeletal muscle index (SMI) derived from L3 vertebral level measurements.

Keywords:

Crohn’s disease body composition hospitalization sarcopenia

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Univariate and multivariate analyses to determine associations with CD phenotype and outcomes.

Main Results:

33.1% of CD patients exhibited sarcopenia.
Sarcopenia was associated with a higher likelihood of hospitalization and penetrating CD phenotype.
Increased SMI correlated with decreased odds of hospitalization (OR: 0.54; P=0.02).

Conclusions:

Automated CT-based body composition analysis is feasible in CD patients.
Sarcopenia and low SMI are linked to increased 1-year hospitalization rates in CD.
SMI may serve as a valuable prognostic tool in managing Crohn's disease.