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Related Experiment Video

Updated: Jan 23, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

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Published on: May 10, 2022

FIT Testing in Iron Deficiency Anemia: A Retrospective Analysis.

Gaius Longcroft-Wheaton¹

¹Portsmouth Hospitals University NHS Trust, Cosham.

Journal of Clinical Gastroenterology

|January 21, 2026

Summary

This summary is machine-generated.

The faecal immunochemical test (FIT) has a lower negative predictive value (NPV) for colorectal cancer in iron deficiency anaemia (IDA) patients than in low-risk groups. Further multicentre studies are needed to determine if FIT is sufficient to rule out colonoscopy in IDA individuals.

Keywords:

FIT cancer faecal immunochemical test iron deficiency anaemia

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Last Updated: Jan 23, 2026

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Area of Science:

Gastroenterology
Oncology
Diagnostic Accuracy

Background:

The faecal immunochemical test (FIT) demonstrates high efficacy in excluding colonic malignancy in low-risk populations, achieving a negative predictive value (NPV) of 99.8%.
The diagnostic performance of FIT in high-risk populations, specifically those with iron deficiency anaemia (IDA), remains uncertain.
This uncertainty has significant implications for healthcare resource allocation globally.

Purpose of the Study:

To determine the NPV of the faecal immunochemical test (FIT) for detecting colorectal cancer in patients diagnosed with iron deficiency anaemia (IDA).

Main Methods:

A single-centre retrospective study was conducted over 12 months.
Paired cases of FIT results below 10 µg Hb/g faeces and IDA were identified, with exclusions for incomplete colonoscopy or CT pneumocolon.
The study calculated the NPV for colorectal cancer, high-risk polyps, and low-risk polyps based on British Society of Gastroenterology (BSG) guidelines.

Main Results:

Of 451 patients with complete colonic investigation, 1.8% (8/451) had colonic malignancy.
The NPV for colorectal cancer was 98.2% (95% CI: 96.9-99.5).
The NPV for advanced polyps was 94.7% (95% CI: 92.6%-96.8%), and for low-risk polyps, it was 73.8% (95% CI: 69.8%-77.9%).

Conclusions:

The NPV of FIT for colorectal cancer in IDA patients appears lower than in asymptomatic, low-risk populations.
It remains uncertain whether this reduced NPV is adequate to obviate the need for colonoscopy in this demographic.
Prospective, multicentre studies are essential to fully evaluate the utility of FIT in IDA patients.