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Updated: Jan 23, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Genetic associations with education have increased and are patterned by socioeconomic context: Evidence from 3
Tim T Morris1, Liam Wright1, Gemma Shireby1
1Centre for Longitudinal Studies, Social Research Institute, Institute of Education, University College London, London WC1H 0NU, United Kingdom.
Abstract:
Social scientists have long sought to investigate whether the predictors of educational attainment (EA) have changed across time. Here, we provide insights by incorporating genetic predictors of education in three nationally representative British birth cohorts born in 1946, 1958, and 1970. We investigated whether individual characteristics as proxied by polygenic indexes (PGIs) for EA and cognition have become more relevant to educational success over time and whether returns to genetic predisposition were moderated by early life socioeconomic background. We present three findings. First, associations between the EA PGI and attainment increased over time, with increasing incremental variance explained by the EA PGI. Second, associations between the cognition PGI and attainment were broadly consistent across cohorts, and there was no clear change in explained variance. Since the EA PGI captures multiple traits related to educational success, factors other than those related to cognition may have become more relevant over time. Third, we observed strong evidence of interaction: Associations between the EA PGI and EA were disproportionately larger among those from more advantaged socioeconomic backgrounds. The strength and pattern of associations varied when using EA PGIs that were less conservatively filtered for SNPs. Our findings suggest EA is influenced by social and genetic factors both independently and jointly. Genetic liability and social background could be considered as two forms of inherited advantage which synergistically influence education attainment.
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