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CAR-T/NK/M-based combination therapies in cancer: A comprehensive review
Shivani Vaja1, Shubhi Khandelwal1, Chaitali Vora1
1Mehta Family School of Biosciences and Biomedical Engineering (MFS-BSBE), Indian Institute of Technology Indore (IITI), Indore, India.
None:
Chimeric Antigen Receptor T (CAR-T) cell therapy, in combination with other treatments or medications, presents a groundbreaking development in cancer immunotherapy. CAR-T immunotherapy has shown remarkable progress, with multiple therapies approved by the US FDA for hematological malignancies. Studies indicate that CAR-NK and CAR-M therapies are more effective against solid tumors than CAR-T-based therapy. The synergistic potential of combining CAR-based therapies with immunomodulatory agents, cytokines, oncolytic viruses, and immune checkpoint inhibitors presents a promising strategy for treating various cancers. This comprehensive review examines the current status and application of CAR-T, CAR-NK, and CAR-M therapies, particularly their integration with immunomodulatory agents and other molecules for treating solid tumors, including glioblastoma, pancreatic, gastric, liver, ovarian, lung, and breast cancers.
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