Spatiotemporal brain dynamics in 8-to-9-year-old children: A comparative study between preterm and term schoolchildren
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View abstract on PubMed
Summary
This summary is machine-generated.Very preterm birth alters brain network dynamics in school-aged children, showing increased spatial extent but reduced temporal flexibility. These changes in functional brain organization may contribute to cognitive vulnerabilities later in life.
Area Of Science
- Neuroscience
- Developmental Neuroscience
- Cognitive Neuroscience
Background
- Preterm birth significantly impacts brain development, increasing risks for long-term cognitive and functional deficits.
- Understanding the effects of very preterm birth on brain network organization is crucial for identifying potential interventions.
Purpose Of The Study
- To investigate the impact of very preterm birth on the spatial and temporal organization of functional brain networks in school-aged children.
- To characterize structure-function coupling in dynamic brain activity using a spatiotemporal connectome framework.
Main Methods
- Utilized multimodal MRI (diffusion-weighted imaging, resting-state fMRI) in 25 very preterm children (born <30 weeks GA) and 25 full-term controls (8-9 years).
- Analyzed Connected Components (CCs) to quantify CC number, height, and width, reflecting co-activation patterns, spatial extent, and temporal span.
- Assessed System Diversity (SD) and Spatiotemporal Diversity (STD) to measure network integrative richness and temporal variability.
Main Results
- CC number decreased with age, consistent with typical development.
- Preterm children exhibited significantly greater CC height, positively associated with processing speed, suggesting altered network co-activation.
- Significantly lower Spatiotemporal Diversity (STD) was observed across all functional networks in the preterm group, indicating reduced temporal flexibility.
Conclusions
- Very preterm birth selectively alters the dynamic engagement of functional brain systems.
- Findings suggest heightened temporal stability and reduced functional flexibility in the brains of children born very preterm.
- These alterations in dynamic network organization may underlie cognitive vulnerabilities observed in this population.
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