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Related Experiment Videos

Caliciviruses infecting monkeys and possibly man.

A W Smith, C Prato, D E Skilling

    American Journal of Veterinary Research
    |February 1, 1978
    PubMed
    Summary

    San Miguel sea lion virus (SMSV) experimentally infected a primate, causing fever and lesions. This calicivirus may also infect humans, as suggested by antibody responses in animal handlers.

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    Area of Science:

    • Veterinary Virology
    • Primate Virology
    • Calicivirus Research

    Background:

    • Caliciviruses are a significant group of viruses with diverse hosts.
    • San Miguel sea lion virus (SMSV) is a notable member of the Caliciviridae family.
    • Previous research has not established experimental primate infection with SMSV.

    Purpose of the Study:

    • To determine if primates are susceptible to SMSV infection.
    • To characterize the clinical and virological outcomes of SMSV infection in a primate model.
    • To investigate potential zoonotic transmission of SMSV.

    Main Methods:

    • Experimental inoculation of an African green monkey with SMSV.
    • Monitoring for clinical signs including fever and lesion development.
    • Virus isolation from lesion material and stool.
    • Serological testing of animal handlers for SMSV antibodies.
    • Confirmation of antibody-virus complexes using immunoelectron microscopy.

    Main Results:

    • The African green monkey developed fever and vesicular lesions post-inoculation.
    • SMSV was successfully recovered from lesions and stool samples.
    • Three individuals handling SMSV showed evidence of neutralizing antibodies.
    • Immunoelectron microscopy confirmed the specificity of the antibody response.

    Conclusions:

    • Primates are experimentally susceptible to SMSV infection.
    • SMSV can cause clinical illness and shedding in primates.
    • Evidence suggests a potential for human infection with SMSV.

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