Transitions of Care From Birth to Outpatient Care for Infants Who Have Been Prenatally Substance-Exposed

Kathleen E Hannan1, Venice Ng Williams2, Sunah S Hwang1

  • 1Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Aurora, Colorado.

Hospital Pediatrics
|January 21, 2026
PubMed

Insights

Improving care transitions for infants prenatally substance-exposed (IPSEs) requires addressing system-level barriers and enhancing communication. Integrating nonmedical personnel and de-siloing clinical care groups are key to optimizing outcomes for IPSEs and their families.

Area of Science:

  • Neonatal care
  • Public health
  • Health services research

Background:

  • Infants prenatally substance-exposed (IPSEs) require coordinated care transitions from birth hospitalization to home.
  • Effective care transitions are crucial for optimizing health outcomes and family support for IPSEs.
  • Identifying multilevel factors influencing these transitions is essential for improving care quality.

Purpose of the Study:

  • To identify multilevel factors impacting care transitions for infants prenatally substance-exposed (IPSEs) and their families.
  • To explore clinician and staff perspectives on facilitators and barriers to successful care transitions.
  • To inform strategies for optimizing the transition of care from inpatient to outpatient settings for IPSEs.

Main Methods:

  • Qualitative study utilizing semistructured interviews with 17 inpatient and outpatient clinicians and clinical staff.
  • Participants were recruited from hospitals involved in the Colorado Hospital Substance Exposed Newborn Quality Improvement Collaborative (CHoSEN QIC).
  • Inductive thematic analysis was conducted using the Exploration, Preparation, Implementation, Sustainment (EPIS) framework.

Main Results:

  • Outer-context facilitators/barriers included the need for standardized patient identification, integrated care systems, and addressing sociopolitical challenges like policy lag.
  • Inner-context facilitators/barriers involved building family rapport, optimizing medical team communication, leveraging nonmedical staff for coordination, and early discharge disposition planning.
  • Themes spanned across multiple levels, highlighting interconnectedness of factors influencing care transitions.

Conclusions:

  • De-siloing clinical care groups and enhancing communication among providers are critical for families affected by substance use.
  • Incorporating key nonmedical personnel into care coordination is essential.
  • Integrating care and communication across systems represents a crucial next step for optimizing care for IPSEs.
Abstract

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