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Updated: Jan 23, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
HealthContradict: Evaluating biomedical knowledge conflicts in language models
Boya Zhang1, Alban Bornet2, Rui Yang3
1Faculty of Medicine, University of Geneva, Geneva, Switzerland. boya.zhang@unige.ch.
Abstract:
How do language models use contextual information to answer health questions? How are their responses impacted by conflicting contexts? We assess the ability of language models to reason over long, conflicting biomedical contexts using HealthContradict, an expert-verified dataset comprising 920 unique instances, each consisting of a health-related question, a factual answer supported by scientific evidence, and two documents presenting contradictory stances. We consider several prompt settings, including correct, incorrect or contradictory context, and measure their impact on model outputs. Compared to existing medical question-answering evaluation benchmarks, HealthContradict provides greater distinctions of language models' contextual reasoning capabilities. Our experiments show that the strength of fine-tuned biomedical language models lies not only in their parametric knowledge from pretraining, but also in their ability to exploit correct context while resisting incorrect context.
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