Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.3K
Impact Loading01:19

Impact Loading

670
Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
670
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

878
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
878
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

465
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
465
Eccentric Loading01:16

Eccentric Loading

922
Eccentric loading is a crucial concept in the study of structural engineering and mechanics, particularly when analyzing the stability and stress distribution in columns. Unlike centric loading, where the force is applied along the centroidal axis, causing uniform compression, eccentric loading occurs when a force is applied off-center. This off-center application introduces not only direct compressive stress but also bending stress, significantly influencing the column's behavior under...
922
Distributed Loads01:19

Distributed Loads

954
Distributed loads are a common type of load that engineers and scientists encounter in various practical situations. Distributed loads often refer to a type of load spread over a surface or a structure and can be modeled as continuous force per unit area.
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
954

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nano-Delivery Systems for Essential Oils in Chitosan-Based Biopolymer Packaging: Structure-Function Relationships and Active-Intelligent Applications.

Foods (Basel, Switzerland)·2026
Same author

Artemisitene formation during UVA-assisted Fenton oxidation of arteannuin B.

Photochemistry and photobiology·2026
Same author

Dual-Route Accessible Zeolites: bridging organic- and inorganic-directed syntheses toward greener zeolite production.

Chemical science·2026
Same author

Genome-wide identification and expression analysis of the Glutathione S-transferase (GST) gene family in Avicennia marina under salt and auxin stress.

BMC plant biology·2026
Same author

Autophagy-Inducing and cfDNA-Scavenging Nanoparticles for Synergistic Atherosclerosis Therapy.

ACS nano·2026
Same author

Ambient particulate matters are associated with attenuation or reversal of positive association between Folate and cognitive function in Chinese older adults.

BMC public health·2026

Related Experiment Video

Updated: Jan 23, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.9K

Injectable Hydrogel Loaded with Magnolol and Nanohydroxyapatite for Treating Periodontitis in Diabetes.

Sihui Li1, Xiaofeng Ren1, Yifan Pu1

  • 1Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Institute of Stomatology, Southwest Medical University, Luzhou 646000, China.

ACS Applied Materials & Interfaces
|January 21, 2026
PubMed
Summary

A novel injectable hydrogel combining Magnolol nanoparticles and nanohydroxyapatite effectively treats diabetic periodontitis by controlling infection, reducing inflammation, and promoting bone regeneration.

Keywords:
diabetic periodontitisinjectable hydrogelmagnolol

More Related Videos

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
09:19

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Published on: September 20, 2020

4.9K
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

5.1K

Related Experiment Videos

Last Updated: Jan 23, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.9K
Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
09:19

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Published on: September 20, 2020

4.9K
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

5.1K

Area of Science:

  • Biomaterials Science
  • Periodontology
  • Endocrinology

Background:

  • Diabetic periodontitis presents complex challenges including refractory infections, inflammation, and impaired bone regeneration.
  • Existing treatments struggle to address the multifaceted nature of this condition.

Purpose of the Study:

  • To develop and evaluate a novel injectable hydrogel for treating diabetic periodontitis.
  • To combine infection control, anti-inflammatory properties, and bone-promoting capabilities in a single therapeutic agent.

Main Methods:

  • Synthesis of a carboxymethyl chitosan/oxidized carboxymethyl cellulose (CMOC) hydrogel encapsulating Magnolol nanoparticles (MAG-NCs) and nanohydroxyapatite (nHA).
  • In vitro assessment of antibacterial activity, reactive oxygen species (ROS) scavenging, macrophage polarization, and osteogenic differentiation.
  • In vivo evaluation in a rat model of diabetic periodontitis.

Main Results:

  • The MAG/nHA/CMOC hydrogel demonstrated sustained Magnolol release, injectable and self-healing properties.
  • Effective inhibition of Porphyromonas gingivalis, ROS scavenging, M1 to M2 macrophage polarization shift, and promotion of osteoblast differentiation.
  • Significant anti-inflammatory and bone-promoting effects observed in vivo, leading to enhanced periodontal repair.

Conclusions:

  • The MAG/nHA/CMOC injectable hydrogel offers a promising personalized strategy for diabetic periodontitis treatment.
  • This approach integrates infection management, inflammation control, ROS scavenging, and periodontal regeneration.