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Updated: Jan 23, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
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Optomechanical Probes with Tailored Material and Shape Asymmetry Assembled Using DNA Origami.

David Daniel Ruiz Arce1, Markéta Benešová2,3, Václav Protiva1

  • 1Department of Dynamics of Molecules and Clusters, J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 3, 18200 Prague, Czech Republic.

Nano Letters
|January 21, 2026
PubMed
Summary

Researchers developed a new method using DNA nanotechnology to create custom microscopic probes. These optomechanical probes, assembled with DNA origami, enable precise environmental sensing and fundamental physics research.

Keywords:
Colloidal ParticlesDNA OrigamiOptical TrappingOptomechanics

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Area of Science:

  • Physics
  • Nanotechnology
  • Biotechnology

Background:

  • Optically trapped microscopic probes are crucial for environmental sensing and studying fundamental physics.
  • Fabricating uniform probes, especially with controlled asymmetries, presents a significant challenge.

Purpose of the Study:

  • To develop a bottom-up strategy for fabricating uniform optomechanical probes with controlled properties.
  • To demonstrate the utility of DNA nanotechnology in creating complex probe structures.

Main Methods:

  • Synthesized Janus-type colloidal heterodimers using DNA origami nanostructures.
  • Interconnected microspheres of different materials and sizes with 24-helix bundle (24HB) DNA origami.
  • Utilized optical tweezers for 2D and 3D manipulation of the assembled probes.

Main Results:

  • Successfully fabricated heterodimers with controlled shape and material asymmetries.
  • Demonstrated precise manipulation of the custom-built probes using optical tweezers.
  • Showcased the DNA origami scaffolds' role in assembly and functionalization.

Conclusions:

  • The DNA nanotechnology approach provides a versatile platform for fabricating custom optomechanical probes.
  • This method overcomes challenges in creating uniform probes with specific asymmetries.
  • Opens new avenues for designing tailored probes for advanced optomechanical experiments.