[Association between body composition and high-sensitivity C-reactive protein in older adults aged 65 years and above in 18 longevity areas in China]
View abstract on PubMed
Summary
This summary is machine-generated.Higher muscle mass may lower inflammation risk in older adults, while increased body fat exacerbates it. Maintaining optimal body composition is key to reducing systemic inflammation, with notable sex-specific differences observed.
Area Of Science
- Gerontology
- Biomarkers of Aging
- Inflammation Research
Background
- Elevated high-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation linked to adverse health outcomes in older adults.
- Body composition, including muscle and fat mass, plays a role in metabolic health and inflammation.
- Understanding these associations is crucial for developing targeted interventions in aging populations.
Purpose Of The Study
- To investigate the relationship between key body composition indicators and elevated hs-CRP levels in Chinese older adults (≥65 years).
- To explore potential sex-specific differences in the association between body composition and inflammation.
- To identify body composition targets for mitigating inflammation risk in elderly populations.
Main Methods
- Cross-sectional study using data from the 2021 China Healthy Ageing and Biomarkers Cohort Study.
- Inclusion of 4,596 older adults, with data on demographics, lifestyle, cognitive function, and medical history.
- Measurement of body composition (muscle mass, fat mass, body fat percentage, visceral fat) via bioelectrical impedance analysis and hs-CRP levels via immunoturbidimetry.
Main Results
- Higher muscle mass was associated with a reduced risk of elevated hs-CRP (Q4 vs. Q1: OR=0.672).
- Increased fat mass, body fat percentage, and visceral fat were significantly associated with a higher risk of elevated hs-CRP (Q4 vs. Q1: ORs ranging from 1.432 to 1.738).
- Sex-specific effects were observed: higher muscle mass reduced inflammation risk in men, while higher fat mass increased risk in women.
Conclusions
- Maintaining higher muscle mass may be protective against systemic inflammation in older adults.
- Conversely, increased fat mass, body fat percentage, and visceral fat are risk factors for elevated hs-CRP.
- Optimizing body composition, considering sex-specific nuances, is a potential strategy for reducing inflammation in the elderly.
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