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Effect and safety of mivacurium chloride and succinylcholine for bronchoscopy: study protocol for a single-center,
Xiang Zhang1, Yongqing Xu1, Jie Li1,2
1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Background:
Succinylcholine is favored for its rapid onset and offset, but its use is limited by adverse effects. Mivacurium chloride, a non-depolarizing relaxant, offers a similar shorter duration and fewer cardiovascular effects, especially without worrying about muscle pain and hyperkalemia, making it a potential alternative in some short-time operations. This study aims to assess the non-inferiority of mivacurium chloride compared to succinylcholine in terms of muscle relaxation effect and safety during flexible bronchoscopy.
Methods:
This is a prospective, single-center, randomized, assessor-blinded, positive-controlled trial. Participants scheduled for flexible bronchoscopy requiring muscle relaxation were randomly assigned to receive either mivacurium chloride or succinylcholine. The primary endpoint is the recovery rate of spontaneous breathing within 15 min after discontinuation of muscle relaxants. Other outcomes, including recovery time at different levels, hemodynamic changes, adverse events, and satisfaction from physicians and patients, are also collected.
Discussion:
This study aims to compare the recovery effect of mivacurium chloride for muscle relaxation during bronchoscopy with succinylcholine, hypothesizing that mivacurium chloride is non-inferior in recovery time and superior in safety and comfort.
Trials Registration:
Chinese Clinical Trial Registry ChiCTR2400091276. Registered on 23 October 2024.
Clinicaltrials:
gov NCT06709066. Posted on 29 November 2024.
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