Leveraging SiO2-Infused COFs for PhotoPyro.
Hyeonji Rha1, Nem Singh1, Amit Sharma2
1Department of Chemistry, Korea University, Seoul, South Korea.
Advanced Healthcare Materials
|January 22, 2026
Summary
This study introduces a novel SiO2@COF nanoplatform for phototherapy. This metal-free material enhances catalytic efficiency and enables precise biological control for advanced precision therapies.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Covalent organic frameworks (COFs) show therapeutic potential in phototheranostics.
- Clinical translation is hindered by COF instability and poor performance in physiological conditions.
Purpose of the Study:
- To develop a stable and high-performance COF-based nanoplatform for phototherapy.
- To overcome the limitations of COFs in physiological environments.
Main Methods:
- Post-synthetic modification (PSM) strategy to coat SiO2 nanoparticles with ultrathin COF layers.
- Utilized Schiff-base condensation of TAPP and PDCA for COF layer formation.
- Created a core-shell SiO2@COF architecture.
Main Results:
- Enhanced photocatalytic NADH oxidation with significantly increased turnover frequency (TOF) under both normoxia and hypoxia.
- Demonstrated robust, oxygen-independent catalytic efficiency.
- Achieved efficient reactive oxygen species (ROS) generation and photon-controlled pyroptosis activation via the caspase-3/GSDME pathway.
Conclusions:
- The SiO2@COF nanoplatform offers enhanced catalytic activity and stability.
- This metal-free system provides precise biological control for phototherapy.
- Represents a promising advancement for next-generation precision phototherapies.
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