Association between the Chinese Visceral Adiposity Index and Multimorbidity in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study
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View abstract on PubMed
Summary
This summary is machine-generated.High visceral adiposity, measured by the Chinese visceral adiposity index (CVAI), significantly increases the risk of developing multiple chronic conditions in Chinese adults. This highlights CVAI as a key factor in multimorbidity development.
Area Of Science
- Gerontology
- Public Health
- Epidemiology
Background
- Visceral adiposity's link to multimorbidity is understudied in Chinese populations.
- The China Health and Retirement Longitudinal Study (CHARLS) provides data for this investigation.
Purpose Of The Study
- To examine the association between visceral adiposity, quantified by the Chinese visceral adiposity index (CVAI), and the incidence of multimorbidity.
- To identify patterns of multimorbidity and their relationship with CVAI.
Main Methods
- A prospective cohort study of 6,410 adults initially free of multimorbidity from the CHARLS dataset.
- CVAI calculated using age, BMI, waist circumference, triglycerides, and HDL cholesterol; multimorbidity defined as ≥2 chronic conditions.
- Latent class analysis (LCA) and Cox regression with restricted cubic splines (RCS) analyzed CVAI's impact on multimorbidity risk.
Main Results
- Over 5 years, 43.8% developed multimorbidity. Each increase in CVAI quartile significantly raised multimorbidity risk (HR 1.20).
- A dose-response relationship was observed between CVAI and multimorbidity incidence.
- LCA identified four multimorbidity clusters; CVAI increments were linked to cardio-metabolic (HR 1.51) and arthritis-renal (HR 1.29) clusters.
Conclusions
- Elevated CVAI is a significant risk factor for incident multimorbidity in Chinese middle-aged and older adults.
- CVAI plays a crucial role in the development of specific multimorbidity patterns, including cardio-metabolic and arthritis-renal clusters.
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