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Updated: Jan 23, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
Sesaminol Ameliorates Age-Related Cognitive Decline and Neuroinflammation by Modulating Microglial Polarization and
Liujie Zheng1, Xinqing Wu1, Fen Zhuge2
1College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Abstract:
Microglia are pivotal regulators of neuroimmune homeostasis in the central nervous system, and their dysregulation is linked to neurodegeneration and brain aging. Among the principal sesame-seed lignans, sesamin has demonstrated robust neuroprotective effects via antioxidant and anti-inflammatory pathways, whereas the neural actions and underlying mechanisms of sesaminol remain undefined. Here, we compared sesaminol with sesamin regarding cognition, neuroinflammation, and microglial polarization in middle-aged mice, and assessed the effects of sesaminol in LPS-challenged mice. In middle-aged mice, sesaminol restored spatial and recognition memory and amplified hippocampal neurotrophic signaling, while sesamin showed only modest benefits. Sesaminol also reversed LPS-induced cognitive deficits in mice. Moreover, sesaminol suppressed oxidative stress and neuroinflammation, and shifted the microglia toward an M2-dominant phenotype, probably in a HIF-1α-dependent manner. Furthermore, sesaminol accelerated Aβ40/42 clearance by upregulating lysosomal functions. Thus, sesaminol restores microglial homeostasis and Aβ clearance to counter chronic and acute cognitive decline and might be one potential antiaging agent.
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