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An Integrated 12C/13C Exchange Platform for Accessing Isotopically-Labeled Ketones via Dual Catalytic C-C
Hui-Qing Geng1, Álvaro Velasco-Rubio1, Eva Jaramillo-Cassà1,2
1Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain.
Abstract:
Herein, we describe an integrated diacylation/acylation platform that formally converts simple ketones into their 13C-labeled homologues. The method relies on the propensity of proaromatic dihydroquinazolinones to generate open-shell species via C-C bond-functionalization aided by photoinduced single-electron transfer prior to interception with a properly labeled 13C-carbonyl derivative. The protocol is characterized by its broad applicability, thus offering a distinct gateway to access 13C-labeled ketones from their parent nonlabeled analogues.
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