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Updated: Jan 23, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
Effect of single xeno-nucleic acid replacement on the fluorescence of DNA-encapsulated silver nanoclusters
Hari Chandana Yadavalli1,2, Riddhi Nagda1,3, Jooyoun Kang4
1Department of Systems Biology, Institute of Life Science and Biotechnology, Yonsei University Seoul 03722 Korea yang@yonsei.ac.kr.
Abstract:
The fluorescent properties of DNA/AgNCs are largely governed by the composition of AgNCs, the nucleobase sequence, and the secondary structure of the DNA template. Here, by systematic incorporation of xeno-nucleic acid modifications, we demonstrate the potential of altering the sugar chemistry of the template DNA backbone, as a novel factor in AgNC fluorescence modulation.
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