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Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
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Tendon Transfer Fixation in Patients With Neuromuscular Disease.

Maia D Regan1, Sarmistha Madan1, Colby M Freeman1

  • 1The Children's Hospital of Philadelphia, Division of Orthopaedics, Philadelphia, PA, USA.

Journal of the Pediatric Orthopaedic Society of North America
|January 22, 2026
PubMed
Summary

Interference screw fixation (ISF) offers a successful alternative for tendon transfers in neuromuscular patients, allowing earlier weight-bearing without increased skin breakdown. This method is effective regardless of the patient's baseline ambulatory status.

Keywords:
Interference screwLower extremityNeuromuscularTendon transfer

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Area of Science:

  • Orthopedic surgery
  • Pediatric orthopedics
  • Neuromuscular disease management

Background:

  • Traditional tendon transfer fixation methods (sutures, buttons) in neuromuscular populations often require non-weight-bearing (NWB) periods and carry risks like pressure sores.
  • Interference screw fixation (ISF) utilizes bioabsorbable screws for tendon fixation, potentially enabling earlier weight-bearing (WB).

Purpose of the Study:

  • To evaluate the success rate and complications of ISF in foot and ankle tendon transfers for neuromuscular patients.
  • To compare ISF with traditional suture fixation methods.

Main Methods:

  • Retrospective review of 102 neuromuscular patients undergoing foot/ankle tendon transfers (2013-2023).
  • Data collected included demographics, neurological diagnosis, and surgical procedures.
  • ISF failure defined as intraoperative pull-out, need for supplementary fixation, or abandonment of ISF.

Main Results:

  • 75% of tendon transfers used ISF, with an overall ISF failure rate of 8.9%.
  • No correlation found between preoperative ambulation and ISF failure (P > .05).
  • ISF group showed significantly earlier postoperative weight-bearing compared to other fixation types (P < .001), with no significant difference in skin breakdown.

Conclusions:

  • ISF is a viable and successful fixation option for foot and ankle tendon transfers in neuromuscular patients, regardless of ambulatory status.
  • ISF facilitates significantly earlier return to full weight-bearing.
  • ISF demonstrated comparable rates of postoperative skin breakdown to other fixation methods.