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Sectioning Mammary Gland Whole Mounts for Lesion Identification
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Neoplastic risk in hyperplastic esophagogastric junction lesions: Comprehensive multicenter study.
Elena De Cristofaro1, Federico Barbaro2, Jérôme Rivory3
1Faculty of Medicine and Surgery, Gastroenterology, University of Rome Tor Vergata, Rome, Italy.
Endoscopy International Open
|January 22, 2026
Summary
Esophagogastric junction (EGJ) hyperplastic lesions can transform into cancer. Non-polypoid morphology, ulceration, and size over 12 mm predict this neoplastic transformation, requiring careful endoscopic assessment and management.
Area of Science:
- Gastroenterology
- Oncology
- Endoscopic Surgery
Background:
- Esophagogastric junction (EGJ) hyperplastic lesions are rare and often benign.
- Their endoscopic appearance is nonspecific, complicating diagnosis.
- Risk factors for neoplastic transformation remain unclear.
Purpose of the Study:
- To identify predictive factors for neoplastic transformation in hyperplastic EGJ lesions.
- To improve diagnostic accuracy and management strategies for these lesions.
Main Methods:
- Multicenter, retrospective study of 91 endoscopically resected hyperplastic EGJ lesions.
- Data collected from endoscopy and pathology reports.
- Multivariable logistic regression used to identify predictive factors for neoplastic transformation.
Main Results:
- 23% of lesions showed neoplastic transformation (dysplasia or adenocarcinoma).
- Independent predictors included non-polypoid morphology (OR 5.48), surface ulceration (OR 11.5), and lesion size (OR 5.48).
- Lesion size > 12 mm significantly predicted neoplastic transformation.
Conclusions:
- Hyperplastic EGJ lesions carry a significant risk of neoplastic transformation.
- Careful endoscopic assessment is crucial for predicting malignancy.
- Appropriate management strategies are needed to ensure complete resection.
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