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Updated: Jan 23, 2026

Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
Published on: March 29, 2018
Stage I placental site trophoblastic tumor with complete response after pembrolizumab
Pierre Descargues1,2, Lua R Eiriksson1,3,4, Pascal Rousset5
1Centre Français de Référence des Maladies Trophoblastiques, Hospices Civils de Lyon, Hôpital Lyon Sud, 69495 Pierre Bénite, France.
Abstract:
•Placental site trophoblastic tumors (PSTT) express PD-L1, making them ideal targets for PD-1 and PD-L1 inhibitors.•For this PSTT patient seeking fertility-sparing treatment, PD-1 inhibition demonstrated complete and sustained response.•Despite anti PD-1 toxicity, there is potential for significant benefit when no alternative fertility-sparing options exists.
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