Related Experiment Video

Updated: Jan 23, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

68.3K

Nobiletin promotes fracture healing by modulating macrophage polarization: a review

Zhiqi Zhang1, Shangyi Liu2, Wenhao Li2

  • 1Department of Burn, Three Gorges University Hospital of Traditional Chinese Medicine & Yichang Hospital of Traditional Chinese Medicine, Yichang, China.

Frontiers in Pharmacology
|January 22, 2026
PubMed

Insights

Nobiletin may enhance fracture healing by modulating macrophage activity. This review explores nobiletin

Area of Science:

  • Biomedical science
  • Cell biology
  • Orthopedic research

Background:

  • Fracture healing involves complex cellular interactions, including macrophages.
  • M1 macrophages promote inflammation and hinder healing, while M2 macrophages aid repair.
  • An M1/M2 imbalance can cause delayed healing or nonunion.

Purpose of the Study:

  • To review the effects of nobiletin on macrophage polarization during fracture healing.
  • To explore potential mechanisms and applications of nobiletin in fracture repair.
  • To provide a research reference for nobiletin's role in bone healing.

Main Methods:

  • Literature review of studies on nobiletin and fracture healing.
  • Analysis of nobiletin's impact on macrophage phenotypes (M1/M2).
  • Investigation of signaling pathways involved in nobiletin's action.

Main Results:

  • Nobiletin shows promise in promoting fracture healing.
  • Evidence suggests nobiletin influences macrophage polarization towards the M2 phenotype.
  • Potential mechanisms involve anti-inflammatory and pro-regenerative pathways.

Conclusions:

  • Nobiletin demonstrates therapeutic potential for enhancing fracture healing.
  • Modulating macrophage balance is a key mechanism.
  • Further research is warranted to optimize nobiletin application in clinical settings.
Keywords:
bone ununionfractureinflammatorymacrophage polarizationnobiletin

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