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Updated: Jan 23, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Mapping antibiotic resistance in Ghana: a narrative review of regional variations in antibiotic-resistant ESKAPEE
Abdulwasid Abubakari1, Rosemary Agbeko2, George Osei-Adjei1
1Department of Science Laboratory Technology, Accra Technical University, Accra, Ghana.
Introduction:
Antibiotic resistance (ABR) is a global health crisis and a significant public health challenge in Ghana. This narrative review aims to uncover the patterned landscape of ABR by systematically assessing regional heterogeneity across three key dimensions: (1) the geographic distribution and intensity of ABR surveillance and research; (2) the prevalence of ESKAPEE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species, and Escherichia coli); and (3) the distribution of their antimicrobial resistance profiles and underlying genetic mechanisms. The review maps data from clinical, animal, and environmental sources to provide a comprehensive sub-national picture.
Methods:
Four online databases (PubMed, Scopus, Web of Science, and African Journals Online) were searched for relevant articles published from 2016 to 2025, a timeframe chosen to align with the development and implementation of Ghana's first National Action Plan (NAP) on AMR (2017-2021). A narrative synthesis was conducted to collate, analyze, and map regional data on ESKAPEE pathogen prevalence, resistance patterns, and underlying genetic mechanisms.
Results:
A total of 48 studies met the inclusion criteria. The findings reveal a significant disparity in research coverage, with a heavy concentration of studies in the Greater Accra (35.4%) and Ashanti (18.6%) regions. Widespread multidrug resistance was evident across all studied regions, with E. coli and K. pneumoniae consistently showing high resistance (>70%) to common antibiotics like ampicillin and third-generation cephalosporins. The review documents the emergence of critical carbapenemase genes (including blaNDM-1 and blaOXA-48), a notable prevalence of methicillin-resistant S. aureus (MRSA), and the detection of the colistin resistance gene mcr-1 in animal sources. Significant heterogeneity in study design and methodology was observed across the included literature.
Conclusion:
ABR in Ghana presents as a patterned landscape rather than a uniform national profile. Stark regional disparities and major surveillance gaps create "blind spots" that can hinder the effective implementation of national policy. Addressing this requires prioritizing surveillance in under-studied regions and standardizing methodologies. Furthermore, region-specific control strategies must be developed using a "One Health" approach, one that integrates surveillance and stewardship interventions across human healthcare, agricultural, and environmental sectors.
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