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Calculation of Compound Intake Levels Using Integrated Food Compound Databases and Food Intake Data.

Marie Y Meima1,2, Joost Westerhout1, Sabina Bijlsma1

  • 1The Netherlands Organization for Applied Scientific Research, Utrecht, The Netherlands.

Current Developments in Nutrition
|January 22, 2026
PubMed
Summary
This summary is machine-generated.

This study estimates dietary compound intake in patients with inflammatory bowel disease (IBD). Calculated intake levels for vitamins, minerals, fatty acids, and polyphenols were found to be plausible, forming a foundation for future food-health research.

Keywords:
FooDBNEVOPhenol-Explorerdietary datafood composition databasesfood compoundsfood frequency questionnairefood intake

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Area of Science:

  • Nutritional Science
  • Molecular Nutrition
  • Dietary Epidemiology

Background:

  • Mechanisms linking diet to disease remain largely unknown.
  • Analyzing food at the molecular compound level offers potential new insights.
  • Previous work integrated three food compound databases.

Purpose of the Study:

  • To combine integrated food compound databases with food intake data.
  • To estimate compound intake levels in patients.
  • To evaluate the plausibility of these estimated intake levels.

Main Methods:

  • Utilized food frequency questionnaire (FFQ) data from 135 adult inflammatory bowel disease (IBD) patients.
  • Translated FFQ data into intake values for 770 compounds.
  • Assessed plausibility by comparing calculated intake percentiles with population data and literature benchmarks.

Main Results:

  • Calculated vitamin and mineral intake p50 values fell within the 5th to 90th percentile of Dutch population data.
  • Intake ranges for fatty acids and polyphenols overlapped with literature values, though with some deviation.
  • Deviations may be attributed to regional dietary variations and lack of standardized benchmarks.

Conclusions:

  • The study provides plausible intake estimates for numerous dietary compounds using Dutch cohort data.
  • This research establishes a foundation for further food-health investigations.
  • The methodology enables analysis of diet at a molecular level for disease research.