One Anastomosis Gastric Bypass in Patients With a BMI ≥50 kg/m²: A Systematic Review and Single-Arm Meta-Analysis of...

The prevalence of individuals with obesity classes 4 and 5 is increasing, with no optimal surgical approach identified. With the rising popularity of one anastomosis gastric bypass (OAGB), we conducted a single-arm meta-analysis to assess its outcomes in this population.

A comprehensive search of PubMed, Scopus, EMBASE, and Cochrane identified studies on OAGB reporting weight loss, comorbidity remission, and complications. Statistical analysis was performed using RStudio 4.4.1. Heterogeneity was assessed using the Cochrane Q test and I² statistics.

Seventeen studies including 2,274 patients (mean age, 40.44 years), were identified. The analysis revealed a rising trend up to 24 months, with a pooled excess weight loss (%) of 68.08% (95% confidence interval [CI], 63.64-72.52; I²=95.6%), and total weight loss (%) of 36.63% (95% CI, 35.34-37.92; I²=84.6%) at 12 months. Diabetes and hypertension remission rates were 82.02% (95% CI, 70.36-89.77; I²=59.5%) and 78.06% (95% CI, 59.05-89.77; I²=84.9%), respectively. The incidence of de novo gastroesophageal reflux disease was 4.38% (95% CI, 0.61-25.59; I²=91.9%).

OAGB can be a valuable option for this population, awaiting long-term data.