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Updated: Jun 16, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Harnessing Frémy's salt for tyrosine-directed bioconjugations
Zachary V Samuels1,2,3, Ava Stoddard1,3,4, Wei-Siang Mark Kao1,3
1Department of Chemistry, Hunter College, City University of New York New York NY 10065 USA bz102@hunter.cuny.edu.
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The current bioconjugation toolbox overwhelmingly comprises strategies that modify lysine and cysteine residues within proteins and peptides. Herein, we have leveraged Frémy's salt (potassium nitrosodisulfonate) to create an approach to bioconjugation predicated on the oxidation of tyrosine residues and the subsequent strain-promoted oxidation-controlled quinone ligation between the resultant 1,2-quinones and trans-cyclooctene-bearing cargoes.

