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Updated: Jan 23, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Metal-coordinated porphyrin COFs enable efficient visible-light-driven photocatalytic NADH regeneration
Qing-Ru Zhao1, Kui Wang2, Xiaokai Gao1
1Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, P. R. China. tancy@sz.tsinghua.edu.cn.
None:
We present three porphyrin-based covalent organic frameworks (COFs), Por-BPy-COF1, Por-RhBPy-COF2, and ZnPor-RhBPy-COF3, synthesized as visible-light-responsive photocatalysts for NADH regeneration. These COFs incorporate porphyrin units that absorb visible light across a broad spectrum (200-680 nm), with Por-RhBPy-COF2 and ZnPor-RhBPy-COF3 further enhanced by rhodium and zinc metal coordination to promote charge separation. Notably, the rhodium-coordinated COFs (Por-RhBPy-COF2 and ZnPor-RhBPy-COF3) exhibited significantly higher catalytic activity (∼41-46% in 1 hour) compared to Por-BPy-COF1 (2.6%), attributed to rhodium's bioinspired role in facilitating NAD+ reduction. Structural stability and sustained catalytic performance were confirmed, with Por-RhBPy-COF2 maintaining >37% activity during a 1-hour cyclic NADH regeneration test. These findings highlight the potential of these COFs for efficient solar-to-chemical energy conversion, advancing sustainable photocatalytic technologies.
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