Impact of Anesthesia Strategy on Infant Pulmonary Function Test Quality and Duration
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View abstract on PubMed
Summary
This summary is machine-generated.Chloral hydrate (CH) shortages necessitate alternatives for infant pulmonary function testing (iPFT) sedation. Ketamine/midazolam (KM), dexmedetomidine (DX), and polypharmacy (PP) show comparable safety and test quality to CH, with some time variations.
Area Of Science
- Pediatric Pulmonology
- Anesthesiology
- Pharmacology
Background
- Chloral hydrate (CH) is the standard sedative for infant pulmonary function testing (iPFT).
- Current CH shortages necessitate exploring alternative sedation strategies for iPFT.
- Evaluating the safety, duration, and quality of these alternatives is crucial.
Purpose Of The Study
- To compare the safety, test duration, and test quality of alternative sedation strategies for iPFT.
- To assess ketamine/midazolam (KM), dexmedetomidine (DX), and polypharmacy (PP) against CH.
Main Methods
- Retrospective chart review of 66 pediatric iPFTs (2019-2021).
- Data abstracted included demographics, sedation agents, adverse events, iPFT type, duration, and quality.
- Bivariate and multivariable analyses compared CH to KM, DX, and PP.
Main Results
- No significant differences in iPFT types or satisfactory test proportions between CH and alternatives.
- Shorter procedure time with KM, shorter induction time with DX; longer recovery time with DX.
- Total testing time was longer with PP (12.0 min increase) vs. CH; no difference for KM or DX.
- Mild adverse events occurred in 3 patients (2 PP, 1 DX).
Conclusions
- Ketamine/midazolam (KM), dexmedetomidine (DX), and polypharmacy (PP) appear to be safe and effective alternatives to CH for iPFT sedation.
- These agents offer viable options amidst CH shortages, with comparable test quality.
- Further research may refine optimal use of these alternative sedatives.
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