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ROS-responsive multifunctional DCS-based micelle hydrogel for simultaneously inhibiting post-resection melanoma

Sha Liu1, Lina Wang2, Yupeng Wang3

  • 1Hebei Key Laboratory of Inorganic Nanomaterials, College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P. R. China. liusha@hebtu.edu.cn.

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This study developed a novel micelle hydrogel (AB@MH) for melanoma treatment. The hydrogel promotes wound healing and suppresses tumor recurrence by releasing anti-cancer drugs in response to reactive oxygen species (ROS).

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Area of Science:

  • Biomaterials Science
  • Cancer Therapy
  • Wound Healing

Background:

  • Delayed healing of post-melanoma resection wounds can lead to tumor recurrence.
  • Effective postoperative management requires simultaneous anti-cancer activity and wound healing promotion.

Purpose of the Study:

  • To develop a multifunctional micelle hydrogel (AB@MH) for integrated post-resection melanoma therapy.
  • To achieve controlled drug release, enhanced anti-tumor efficacy, and accelerated wound repair.

Main Methods:

  • Fabrication of a dodecyl-modified chitosan (DCS)-based hydrogel co-loaded with apigenin and BMS-202 within ROS-responsive nanomicelles.
  • Utilizing Schiff base linkages and hydrogen bonding for hydrogel formation.
  • In vivo evaluation in a melanoma resection model.

Main Results:

  • The AB@MH formulation demonstrated ROS-triggered drug release, minimizing systemic toxicity.
  • Apigenin showed selective cytotoxicity against tumor cells and bacteria, inducing immunogenic cell death (ICD).
  • Combined therapy with BMS-202 enhanced anti-tumor efficacy without harming normal cells.
  • AB@MH significantly suppressed tumor recurrence and accelerated wound healing in vivo.

Conclusions:

  • The developed AB@MH is a safe and effective multifunctional material for postoperative melanoma treatment.
  • This approach successfully integrates anti-tumor therapy and wound healing enhancement.
  • The study highlights a promising strategy for improving outcomes in post-resection cancer care.