Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Translesion DNA Polymerases02:10

Translesion DNA Polymerases

11.1K
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
11.1K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.6K
Overview
40.6K
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

6.3K
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of optimized fluorogenic DNA aptamers for a portable one-pot CRISPR-Cas12a platform for rapid and sensitive detection of monkeypox virus and chikungunya virus.

Journal of advanced research·2026
Same author

Beta-Glucan modulates monocyte plasticity and differentiation capacity to mitigate DSS-induced colitis.

eLife·2026
Same author

Integrative analysis reveals intra-tumoral microbial enterotypes shape host transcriptomes in colorectal cancer.

Cell reports·2026
Same author

Pembrolizumab plus high-dose IL-2 in advanced clear cell renal cell carcinoma: six-year survival outcomes and molecular signatures from a phase 2 trial.

Nature communications·2026
Same author

Cold-induced Cpt1 repression uncouples lipid mobilization from oxidation and drives lipotoxicity during honeybee metamorphosis.

Insect biochemistry and molecular biology·2026
Same author

Electrothermal decoupling for investigating tumor treating fields of glioblastoma.

Physics in medicine and biology·2026

Related Experiment Video

Updated: Jan 23, 2026

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
08:00

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

8.7K

Intraepithelial Penile Lesions.

Hongzhi Xu1, Jasreman Dhillon

  • 1Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Advances in Anatomic Pathology
|January 22, 2026
PubMed
Summary
This summary is machine-generated.

Penile intraepithelial lesions include condyloma acuminatum and penile intraepithelial neoplasia (PeIN). These lesions are classified as HPV-associated or HPV-independent, with distinct characteristics and associated risk factors.

Keywords:
condyloma acuminatumextramammary Paget diseasemelanoma in situpenile intraepithelial neoplasia

More Related Videos

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
03:05

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Published on: February 16, 2024

1.5K
Microscopic Replantation of Penile Glans Amputation Due to Circumcision
07:28

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

24.3K

Related Experiment Videos

Last Updated: Jan 23, 2026

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
08:00

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

8.7K
Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
03:05

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Published on: February 16, 2024

1.5K
Microscopic Replantation of Penile Glans Amputation Due to Circumcision
07:28

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

Published on: June 3, 2022

24.3K

Area of Science:

  • Urology
  • Dermatopathology
  • Oncology

Background:

  • Intraepithelial penile lesions encompass non-neoplastic (e.g., condyloma acuminatum) and preneoplastic (penile intraepithelial neoplasia - PeIN) conditions.
  • Condyloma acuminatum is typically linked to low-risk human papillomavirus (HPV) types 6 and 11, though high-risk HPV can coexist.
  • PeIN is categorized as either HPV-associated or HPV-independent, with HPV-associated PeIN being more common in Western regions.

Purpose of the Study:

  • To provide a comprehensive overview of intraepithelial penile lesions.
  • To differentiate between HPV-associated and HPV-independent PeIN based on morphology and molecular markers.
  • To discuss associated conditions and rare penile lesions like Extramammary Paget disease and penile melanoma in situ.

Main Methods:

  • Morphological classification of penile intraepithelial neoplasia (PeIN) subtypes.
  • Immunohistochemical staining for p16 and p53.
  • High-risk human papillomavirus (HPV) in situ hybridization (ISH).
  • Review of genetic alterations (TP53, PIK3CA, HRAS) in HPV-independent PeIN.

Main Results:

  • HPV-associated PeIN subtypes include basaloid, warty, mixed, pagetoid, clear-cell, and spindle-cell, typically p16-positive and wild-type p53.
  • HPV-independent PeIN is more prevalent in high-incidence penile cancer regions and associated with factors like lichen sclerosus.
  • Rare penile lesions such as Extramammary Paget disease and primary penile melanoma in situ can occur.

Conclusions:

  • Intraepithelial penile lesions present diverse histopathological features and etiological associations.
  • Accurate classification of PeIN is crucial for understanding prognosis and guiding management.
  • Further subclassification of differentiated PeIN is an evolving area of research.