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Related Concept Videos

Dietary Connections01:23

Dietary Connections

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In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
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Regulation of Food Intake01:30

Regulation of Food Intake

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Regulation of Water Intake01:25

Regulation of Water Intake

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Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
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Proteins: Dietary Sources and Requirements01:28

Proteins: Dietary Sources and Requirements

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Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Association Areas of the Cortex01:21

Association Areas of the Cortex

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Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
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Related Experiment Video

Updated: Jan 23, 2026

'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake
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'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake

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Association Between EGFR Expression in Non-Small Cell Lung Cancer and Dietary Legume Intake.

Chengman Wang1,2, Fang Fu1,2, Yu Zhang1,2

  • 1School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.

Current Drug Targets
|January 22, 2026
PubMed
Summary

Higher legume intake in non-small cell lung cancer (NSCLC) patients is linked to reduced epidermal growth factor receptor (EGFR) expression. This dietary factor may also decrease the risk of postoperative recurrence, suggesting a potential role in disease management.

Keywords:
Non-small cell lung cancerdietary factorsepidermal growth factor receptorimmunohistochemistrylegumesnutritional epidemiology.tumor progression

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Area of Science:

  • Oncology
  • Nutritional Science
  • Molecular Biology

Background:

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality.
  • Epidermal growth factor receptor (EGFR) is a key target in NSCLC treatment.
  • Dietary factors may influence cancer progression and treatment outcomes.

Purpose of the Study:

  • To investigate the association between legume food intake frequency and EGFR expression in NSCLC tissues.
  • To explore the correlation between legume intake and postoperative recurrence in NSCLC patients.

Main Methods:

  • Retrospective analysis of clinical data from 93 NSCLC patients.
  • Assessment of EGFR expression using immunohistochemistry.
  • Classification of patients based on legume intake frequency (low vs. high).
  • Propensity score matching to control for confounding factors.

Main Results:

  • EGFR positivity was significantly higher in patients with recurrence or metastasis (78.6%) compared to those without progression (47.6%).
  • Patients with high-frequency legume intake showed significantly lower EGFR positivity (42.9%) than those with low-frequency intake (76.2%).
  • High legume intake was associated with a lower risk of postoperative recurrence.

Conclusions:

  • Increased legume consumption correlates with reduced EGFR expression in NSCLC.
  • Higher legume intake may be associated with better postoperative outcomes in NSCLC patients.
  • Legume consumption might modulate NSCLC progression via EGFR regulation, warranting further investigation.