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Colchicine in Patients With Recent Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized

Areesha Moiz1, Tetiana Zolotarova1, Mark J Eisenberg1,2,3,4,5

  • 1Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital McGill University Montreal QC Canada.

Journal of the American Heart Association
|January 22, 2026
PubMed

Insights

Colchicine did not significantly improve cardiovascular outcomes in patients with recent myocardial infarction. Further research is needed to clarify the role of this anti-inflammatory agent in post-myocardial infarction care.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Trials

Background:

  • The efficacy of colchicine, an anti-inflammatory drug, in improving cardiovascular outcomes after myocardial infarction is not well-established.
  • This study aimed to assess colchicine's effectiveness and safety compared to placebo in patients experiencing recent myocardial infarction.

Purpose of the Study:

  • To evaluate the impact of colchicine on major adverse cardiovascular events (MACE) in patients who have recently had a myocardial infarction.
  • To determine the safety profile of colchicine, including adverse events, in this patient population.

Main Methods:

  • A systematic literature search was conducted across major databases (MEDLINE, Embase, Cochrane Library) for randomized controlled trials.
  • Five randomized controlled trials involving 6,620 patients on colchicine and 6,625 on placebo were analyzed.
  • The primary endpoint was MACE, with secondary endpoints including MACE components and safety outcomes, analyzed using random-effects models.

Main Results:

  • No statistically significant difference in MACE was observed between the colchicine and placebo groups (8.2% vs. 9.3%).
  • Analyses of individual MACE components did not yield conclusive results.
  • Colchicine use did not lead to an increased incidence of overall or serious adverse events compared to placebo.

Conclusions:

  • Current evidence suggests that colchicine, as an adjunct to standard therapy, does not conclusively impact MACE in patients with recent myocardial infarction.
  • The available data, with a median follow-up of one year, remain insufficient to establish colchicine's definitive role in this clinical setting.
Abstract

Keywords:
colchicinemajor adverse cardiovascular eventmeta‐analysismyocardial infarction

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