Preinvasive lesion creation prevalence of other HPV types other than HPV type 16-18

This study aims to investigate the prevalence of preinvasive lesions in cytology cases of high-risk human papillomavirus (HR-HPV) types other than types 16-18.

A retrospective file scan of 342 patients with normal cytology was performed between January 2016 and April 2019 in our hospital's obstetrics and gynecology outpatient clinic. In the first group, with the exception of HR-HPV type positivity, normal cytology and preinvasive lesions were present as a result of biopsy. In the second group, women were HPV type 16-18 positive, had normal cervical cytology, and were found to have preinvasive lesions as a result of biopsy. At the end of the study, we calculated the percentages of HPV types seen in preinvasive lesions.

Three hundred and forty-two patients with normal cytology were included in our study. The average age of women was 41.09±10.61. In 58 (16.9%) patients with 342 HR-HPV type positivity, preinvasive lesions were detected as a result of biopsy. High-grade squamous intraepithelial lesion-low-grade squamous intraepithelial lesion was reported in 54 (15.7%) cases, squamous cell carcinoma in 3 (0.92%) cases, and mixed surface epithelial carcinoma (endometrioid adenocarcinoma 95%, clear cell carcinoma 5%) in 1 (0.3%) case. The age variable was not significant in biopsy subgroups (p>0.05).

Among the biopsy results with preinvasive lesions, approximately half were positive for HPV type 16 or 18, and these cases were identified accordingly. Colposcopy and biopsy should be recommended in suspicious lesions, even if cytology is normal, since other HR-HPV types may also have certain rates of preinvasive and invasive lesions.