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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
Clinical and pathophysiological significance of circ-0049271 in acute ST-segment elevation myocardial infarction
Huocheng Liao1,2, Chun Xiao2, Weiwei Li2
1The First School of Clinical Medicine, Southern Medical University, P. R. China.
Insights
Circular RNA circ-0049271 is upregulated in ST-segment elevation myocardial infarction (STEMI) patients, correlating with myocardial injury and coronary lesion severity. This finding supports its potential as a diagnostic biomarker for acute myocardial infarction.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Biomarker Discovery
Background:
- ST-segment elevation myocardial infarction (STEMI) is a severe coronary artery disease causing significant myocardial damage.
- Circular RNAs (circRNAs) are increasingly recognized as key regulators in cardiovascular diseases.
- Understanding circRNA roles in STEMI is crucial for developing new diagnostic and therapeutic strategies.
Purpose of the Study:
- To investigate the expression levels of circ-0049271 in STEMI patients.
- To analyze the clinical associations of circ-0049271 with disease severity and cardiac function.
- To explore the response of circ-0049271 to oxidative stress in vitro.
Main Methods:
- Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to measure circ-0049271 expression in STEMI patients and healthy controls.
- Correlations were assessed between circ-0049271 levels and clinical parameters like Gensini score, cardiac biomarkers, and left ventricular ejection fraction.
- Human umbilical vein endothelial cells were subjected to hydrogen peroxide treatment to model oxidative stress and evaluate circRNA regulation.
Main Results:
- circ-0049271 expression was significantly higher in STEMI patients compared to controls and remained elevated post-intervention.
- Elevated circ-0049271 levels positively correlated with Gensini score, creatine kinase-myocardial band, and serum potassium, and negatively with left ventricular ejection fraction.
- In vitro studies showed increased circ-0049271 expression, elevated oxidative stress markers, and decreased superoxide dismutase activity under hydrogen peroxide exposure.
Conclusions:
- circ-0049271 is significantly upregulated in STEMI.
- The expression of circ-0049271 is closely associated with myocardial injury, coronary lesion burden, and oxidative stress.
- circ-0049271 shows promise as a potential diagnostic biomarker and therapeutic target for acute myocardial infarction.
Abstract:
ObjectiveST-segment elevation myocardial infarction is a life-threatening coronary artery disease associated with extensive myocardial injury. Circular RNAs are emerging regulators in cardiovascular disease. This study examined circ-0049271 expression in ST-segment elevation myocardial infarction, its clinical associations, and responsiveness to oxidative stress.MethodsFifty-five ST-segment elevation myocardial infarction patients and 35 healthy controls were enrolled. Blood was collected before percutaneous coronary intervention and at 0.5 and 48 h after the intervention. circ-0049271 expression was measured using quantitative reverse transcription polymerase chain reaction, and its correlations with the Gensini score, ischemic duration, cardiac biomarkers, and left ventricular ejection fraction were assessed. Human umbilical vein endothelial cells were exposed to hydrogen peroxide to assess circular RNA regulation under oxidative stress.Resultscirc-0049271 expression was elevated in ST-segment elevation myocardial infarction patients versus controls (p < 0.001) and remained high after percutaneous coronary intervention. It was correlated positively with the Gensini score (r = 0.444), creatine kinase-myocardial band (r = 0.427), and serum potassium (r = 0.322) and negatively with left ventricular ejection fraction (r = -0.281). Receiver operating characteristic analysis yielded an area under the curve of 0.788. In human umbilical vein endothelial cells, circ-0049271 expression increased in a dose-dependent manner with hydrogen peroxide treatment, with elevated oxidative stress markers and reduced superoxide dismutase activity.Conclusionscirc-0049271 is upregulated in ST-segment elevation myocardial infarction and is correlated with myocardial injury, coronary lesion burden, and oxidative stress, supporting its potential as a diagnostic biomarker and therapeutic target in acute myocardial infarction.
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