Related Experiment Video

Updated: Jan 23, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Nuclear Receptor Nur77: A Key Factor and Potential Therapeutic Target in the Aging Regulatory Network

Feng Chen1, Zhiheng Xu2, Xue Bai3

  • 1Department of Comprehensive Ward, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|January 22, 2026
PubMed

Insights

Aging involves cellular decline, but the Nur77 protein shows promise in regulating key aging processes. Targeting Nur77 may offer new strategies to delay aging and combat age-related diseases.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Cellular Biology

Background:

  • Aging is characterized by functional decline, disrupted homeostasis, and reduced regeneration.
  • Molecular events like genomic instability and metabolic dysfunction drive aging and age-related diseases.
  • Targeting key molecular pathways offers potential to slow aging and disease progression.

Purpose of the Study:

  • To systematically analyze the regulatory roles of Nur77 in aging.
  • To explore Nur77's function in age-related mechanisms and diseases.
  • To discuss Nur77's potential as a diagnostic and therapeutic target for aging.

Main Methods:

  • Comprehensive literature review on Nur77 structure and function.
  • Analysis of Nur77's involvement in cellular homeostasis, mitochondrial function, autophagy, and protein quality control.
  • Exploration of Nur77's role in age-related diseases.

Main Results:

  • Nur77 (an NR4A nuclear receptor) is crucial for stress response, energy sensing, and inflammation.
  • Nur77 plays a role in maintaining stem cell homeostasis and repairing mitochondrial damage.
  • Nur77 regulates autophagy and protein quality control, key processes in aging.

Conclusions:

  • Nur77 is a significant regulator of core aging mechanisms.
  • Targeting the Nur77 signaling pathway presents a promising avenue for developing novel anti-aging strategies.
  • Further research into Nur77's synergistic effects could unlock new therapeutic potentials for age-related conditions.
Keywords:
Nur77age‐related diseaseagingmolecular mechanismtherapeutic target

More Related Videos

Generation of Human Chimeric Antigen Receptor Regulatory T Cells10:29

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

2.3K
Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

10.7K

Related Concept Videos

Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
206
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
2.4K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.6K
Nuclear Transmutation03:20

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
20.5K
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
8.7K
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.3K