Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

415
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
415
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

286
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
286
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

208
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
208
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

314
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
314
Feedback Inhibition00:46

Feedback Inhibition

56.9K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
56.9K
Venous Return01:04

Venous Return

11.8K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
11.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Systematic Review of Registry and Large Database Studies Comparing Contemporary Cementless and Cemented Total Knee Arthroplasty.

The Journal of arthroplasty·2026
Same author

Outcomes of gastrocnemius flap coverage during treatment of periprosthetic joint infection of the knee: Planned versus unanticipated flap timing.

Journal of clinical orthopaedics and trauma·2026
Same author

Soluble Thrombomodulin Links Viremia and Mortality During COVID-19: Results From the ACTIV-4a Trial.

Journal of the American Heart Association·2026
Same author

Outcomes of Metaphyseal Versus Diaphyseal Stems in Conversion Total Hip Arthroplasty After Intramedullary Nailing.

The Journal of arthroplasty·2026
Same author

Endothelial cell-derived plasminogen activator inhibitor-1 potentiates thrombosis in antiphospholipid syndrome.

Journal of autoimmunity·2026
Same author

Retaining Well-Balanced Articulating Metal-on-Polyethylene Total Knee Spacers for Periprosthetic Joint Infection: A Potential Alternative to Two-Stage Exchange.

The Journal of arthroplasty·2026

Related Experiment Video

Updated: Jan 23, 2026

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

3.2K

PAI-1 Inhibition in experimental venous thrombosis.

Maxim E Shaydakov1,2, Cory D Emal3, Joshua P Rainey4

  • 1Vascular and Endovascular Surgery, WellSpan Health, York, PA, USA.

Phlebology
|January 22, 2026
PubMed
Summary
This summary is machine-generated.

A new PAI-1 inhibitor, MDI-2268, shows significant antithrombotic effects in a mouse model of venous thrombosis. This novel pro-fibrinolytic agent effectively reduces thrombus weight without increasing bleeding time.

Keywords:
PAI-1inhibitorplasminogenvenous thrombosis

More Related Videos

Electrolytic Inferior Vena Cava Model EIM of Venous Thrombosis
06:03

Electrolytic Inferior Vena Cava Model EIM of Venous Thrombosis

Published on: July 12, 2011

17.7K
Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

16.0K

Related Experiment Videos

Last Updated: Jan 23, 2026

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

3.2K
Electrolytic Inferior Vena Cava Model EIM of Venous Thrombosis
06:03

Electrolytic Inferior Vena Cava Model EIM of Venous Thrombosis

Published on: July 12, 2011

17.7K
Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

16.0K

Area of Science:

  • Pharmacology
  • Thrombosis Research
  • Drug Development

Background:

  • Plasminogen activator inhibitor-1 (PAI-1) plays a key role in thrombosis.
  • A novel PAI-1 inhibitor, MDI-2268, has been developed.
  • Evaluating the efficacy and safety of MDI-2268 is crucial for potential therapeutic applications.

Purpose of the Study:

  • To assess the antithrombotic effects of MDI-2268 in an in vivo model of acute venous thrombosis (VT).
  • To evaluate the safety profile of MDI-2268, specifically its effect on bleeding time.
  • To compare the efficacy of MDI-2268 with enoxaparin, a standard anticoagulant.

Main Methods:

  • An electrolytic injury model of VT was established in C57BL/6 mice.
  • Mice were treated with different doses of MDI-2268, enoxaparin, or a combination.
  • Thrombus weight and tail bleeding time were measured on Day 2 post-injury.

Main Results:

  • MDI-2268 demonstrated a dose-dependent reduction in thrombus weight.
  • Both MDI-2268 (3 mg/kg) and enoxaparin significantly reduced thrombus weight compared to controls.
  • MDI-2268 did not significantly prolong tail bleeding time at the tested doses.

Conclusions:

  • MDI-2268 is a novel pro-fibrinolytic agent with potent antithrombotic activity.
  • MDI-2268 shows a favorable safety profile, with no significant increase in bleeding time.
  • MDI-2268 represents a promising therapeutic candidate for managing acute venous thrombosis.