Conference report: current advances in embryo model research at the International Dutch Embryo Model Meeting 2025

Area of Science:

• Developmental Biology
• Stem Cell Biology
• Bioethics

Background:

• The study of early human development is crucial for understanding congenital disorders and improving reproductive technologies.
• In vitro embryo models offer a promising alternative for studying embryonic development without using traditional embryos.
• Previous Dutch meetings focused on embryo modeling, culminating in the first international gathering.

Purpose of the Study:

• To review the proceedings and key discussions from the International Dutch Embryo Model Meeting.
• To highlight advancements in the creation and application of in vitro embryo-like structures.
• To provide an overview of expert insights into embryo modeling research and its ethical implications.

Main Methods:

• The meeting featured invited international speakers, academic and industry presentations, and poster sessions.
• Sessions were organized around key areas: pluripotency, blastoids, gastruloids, and gametes.
• An interactive ethics session facilitated discussions on the opportunities and risks associated with embryo research.

Main Results:

• Significant progress in studying embryonic development using in vitro embryo-like structures was presented.
• Discussions covered the latest research in blastoids, gastruloids, and gamete development.
• The ethical landscape of embryo modeling was explored, identifying both potential benefits and concerns.

Conclusions:

• The International Dutch Embryo Model Meeting successfully convened leading experts to share progress in embryo modeling.
• In vitro embryo models are advancing the study of early development, with ongoing ethical discussions shaping future research.
• Continued international collaboration is vital for the responsible advancement of embryo modeling research.