Related Experiment Video
Updated: Jan 23, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Dupilumab as maintenance therapy in steroid-dependent eosinophilic enteritis: a multidisciplinary approach
Íñigo Roa Esparza1, Irene Arteagoitia Casero2, Mario Salvador Argueta Valdez1
1Gastroenterology, Hospital Universitario de Cruces, Spain.
Abstract:
Eosinophilic enteritis is a rare immune-mediated disorder for which systemic corticosteroids remain the mainstay of treatment during acute flares, although no standardized maintenance therapy exists and some patients develop recurrent disease requiring repeated steroid courses. We report the case of a 27-year-old man with steroid-dependent eosinophilic enteritis characterized by recurrent flares with abdominal pain, diarrhea, ascites, and peripheral eosinophilia. After exclusion of alternative causes of eosinophilia through a multidisciplinary evaluation, off-label dupilumab was initiated, allowing complete corticosteroid withdrawal, with good tolerability. After one year of follow-up, he maintained remission and was able to reintroduce previously restricted foods, supporting its potential role as a steroid-sparing maintenance therapy in selected patients with eosinophilic enteritis.
Related Concept Videos
Gene Therapy
Maintenance of the ES Cell State
Drug Delivery: Enteral Route
Frequency-dependent Selection
Routes of Drug Administration: Enteral
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Self-Evaluation Maintenance Model

