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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
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Deciphering Candida's Genomic Influence on Oral Squamous Cell Carcinoma: A Bioinformatics Approach.

Jothiha Shree1, Suganya Panneer Selvam1, Nitya Krishnasamy1

  • 1Department of Oral Pathology & Oral Biology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India, Tamil Nadu, Chennai, India.

Asian Pacific Journal of Cancer Prevention : APJCP
|January 22, 2026
PubMed
Summary

Candida infection drives oral cancer (OSCC) progression via immune signaling pathways. Key genomic regions on chromosomes 2, 9, and 16 may offer therapeutic targets for this complex interplay.

Keywords:
BioinformaticsSTRING databasecancer researchcandidachromosomal mapping

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Area of Science:

  • Oral Squamous Cell Carcinoma (OSCC) research
  • Mycology and Immunology
  • Bioinformatics and Computational Biology

Background:

  • Candida infection is linked to Oral Squamous Cell Carcinoma (OSCC) progression.
  • Understanding molecular mechanisms is crucial for OSCC development insights and therapeutic targets.
  • Bioinformatics analysis explores genes in Candida-associated OSCC progression.

Purpose of the Study:

  • Investigate gene networks and biological pathways in OSCC progression due to Candida infection.
  • Identify chromosomal loci involved in Candida-mediated OSCC development.
  • Utilize bioinformatics approaches for comprehensive analysis.

Main Methods:

  • Protein-protein interaction (PPI) network analysis using STRING database.
  • Enrichment analysis of immune and inflammatory biological pathways.
  • Gene Ontology (GO) term examination and chromosomal mapping of enriched genes.

Main Results:

  • Cytokine-cytokine receptor interaction pathway showed significant enrichment (~80-fold) in immune modulation.
  • Other enriched pathways include viral protein interactions, DNA-sensing, and Th17 cell differentiation.
  • Identified immune dysregulation (macrophage proliferation, IL-33, interferon) and key genomic regions on chromosomes 2, 9, 12, and 16.

Conclusions:

  • Immune signaling, especially cytokine interactions, is critical in Candida-mediated OSCC progression.
  • Chromosomal loci on chromosomes 2, 9, and 16 may contain key genes for therapeutic targeting.
  • Findings enhance understanding of immune-driven OSCC mechanisms in Candida infections.