Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Primary Active Transport01:47

Primary Active Transport

197.0K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
197.0K
Genetic Screens02:46

Genetic Screens

5.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.6K
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

60.2K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.2K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.0K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.0K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

841
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
841
Primary Distribution01:28

Primary Distribution

534
Primary distribution systems deliver electrical power from substations to consumers through various voltage classes, with 15-kV class voltages being predominant among U.S. utilities. Older 2.5- and 5-kV classes are being replaced by 15-kV primaries, while higher 25- to 34.5-kV classes are used in high-density urban areas and rural regions with long feeders. Three-phase, four-wire multigrounded systems are widely employed for balanced power delivery, using the neutral wire as a grounding point.
534

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pregnancy in the broad phenotype and genotype spectrum of disease-causing desmosomal variant-positive women.

Journal of cardiovascular medicine (Hagerstown, Md.)·2026
Same author

Evaluating the Whole Patient: Lessons from the Pre-CKM Era Toward Integrated Cardio-Kidney-Liver-Metabolic Care.

Life (Basel, Switzerland)·2026
Same author

An expert opinion on heart failure in hypertensive heart disease.

European journal of heart failure·2026
Same author

Untreated, uncontrolled and below-target hypertension in southern Africa: a population-based prevalence and care cascade assessment in rural Lesotho.

BMJ global health·2026
Same author

Lay community health worker-led care with mobile decision support for uncontrolled hypertension: a cluster-randomized trial.

Nature medicine·2026
Same author

KCNQ1 and GJA1 Variants Associated With Arrhythmogenic Right Ventricular Cardiomyopathy With a Lethal Outcome.

JACC. Case reports·2025

Related Experiment Video

Updated: Jan 23, 2026

Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish
09:50

Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish

Published on: April 10, 2020

8.7K

[Primary hyperaldosteronism - screening, work-up, treatment].

Elisa Bally1, Thilo Burkard1,2,3, Matthias Betz1,2,4

  • 1Universitäres Zentrum für Hypertonie, Medizinische Poliklinik, Universitätsspital Basel.

Praxis
|January 22, 2026
PubMed
Summary

Primary hyperaldosteronism is a common cause of high blood pressure. Early detection via aldosterone-to-renin ratio testing and appropriate treatment, such as surgery or medication, can effectively manage this condition.

Keywords:
Arterial hypertensionaldosteronealdosterone-to-renin ratioprimary hyperaldosteronismspironolactone

More Related Videos

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
08:29

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

Published on: October 2, 2014

15.2K
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.6K

Related Experiment Videos

Last Updated: Jan 23, 2026

Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish
09:50

Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish

Published on: April 10, 2020

8.7K
Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
08:29

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

Published on: October 2, 2014

15.2K
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.6K

Area of Science:

  • Endocrinology
  • Cardiology
  • Nephrology

Background:

  • Primary hyperaldosteronism is a frequent and treatable cause of secondary arterial hypertension.
  • Screening for primary hyperaldosteronism is recommended for all hypertensive patients using the aldosterone-to-renin ratio.
  • Diagnostic workup includes confirmatory testing, adrenal imaging, and adrenal vein sampling.

Purpose of the Study:

  • To outline the diagnostic and treatment strategies for primary hyperaldosteronism.
  • To emphasize the importance of early case finding and confirmation.

Main Methods:

  • Aldosterone-to-renin ratio for case finding.
  • Confirmatory testing.
  • Adrenal gland imaging.
  • Adrenal vein sampling for localization.
  • Surgical or medical management based on etiology.

Main Results:

  • Primary hyperaldosteronism is a prevalent condition.
  • Timely diagnosis and treatment lead to improved outcomes in arterial hypertension.
  • Unilateral adrenal secretion is best treated with laparoscopic adrenalectomy.
  • Bilateral secretion requires medical therapy with mineral corticoid receptor antagonists.

Conclusions:

  • Primary hyperaldosteronism is a significant contributor to secondary hypertension.
  • A systematic approach to diagnosis and tailored treatment is crucial.
  • Effective management strategies exist for both unilateral and bilateral forms of the disease.