Related Experiment Video
Updated: Jan 23, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
High Recurrence Rates of Osteoid Osteoma Treated With Open Surgery and Radiofrequency Ablation
Annika Y Myers1, Adrian Lin2, Abigail N Padilla1
1Children's Hospital Los Angeles, Los Angeles, California, USA.
Background And Objectives:
Osteoid Osteoma (OO) is a painful, benign bone tumor that can be treated surgically with en bloc resection, curettage, and radiofrequency ablation (RFA). This study aims to measure recurrence rates after initial treatment by treatment type and to examine clinical factors associated with recurrence.
Methods:
A retrospective review of patients with an OO diagnosis was performed using a pathology database from a tertiary pediatric hospital between November 1, 2004 and July 1, 2024. Statistical analysis examined the relationships among surgical technique, recurrence, and clinical variables.
Results:
24 patients met inclusion criteria with a median follow-up of 1.41 years (interquartile range, IQR 2.0) and a median age at treatment of 9.92 years (IQR 5.8-13.5). Twelve patients (50.0%) experienced symptomatic tumor recurrence, with a median time to recurrence of 0.92 years (IQR 0.1-3.0). Of those with tumor recurrence, five patients were initially treated with excision and curettage, while the remaining nine underwent RFA. There was no significant correlation between recurrence and surgical intervention (p = 0.667), age at initial surgery (p = 0.468), or patient sex (p = 0.667).
Conclusions:
Surgical management of pediatric OO is linked to high recurrence rates, and recurrence is not related to surgical intervention, age, or patient sex.
Related Concept Videos
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences
Reaction Rate
The mathematical representation of the change in the concentration of reactants and products, over time, is the rate...
Speciation Rates
Related Rates
Measuring Reaction Rates
Rate-Determining Steps
In a multistep reaction mechanism, one of the elementary steps progresses significantly slower than the others. This slowest step is called the rate-limiting step (or rate-determining step). A reaction cannot proceed faster than its slowest step, and hence, the rate-determining step limits the overall reaction rate.
The concept of rate-determining step can be understood from the analogy of a 4-lane freeway with a short-stretch of traffic-bottleneck caused due to...

