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  1. Home
  3. Telitacicept For Childhood Hspn: A Prospective Self-controlled Study.
  1. Home
  3. Telitacicept For Childhood Hspn: A Prospective Self-controlled Study.

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Telitacicept for childhood HSPN: A prospective self-controlled study.

Hanhan Zhang1, Dan Song2, Ke Song1

  • 1Pediatric Nephrology and Purpura Center, Children's Hospital, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, 450000, China.

Clinical Rheumatology
|January 22, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Telitacicept (RC18) effectively treats Henoch-Schönlein Purpura Nephritis (HSPN) in children by reducing urine protein and red blood cells. This study confirms its good clinical effects and safety profile for pediatric HSPN management.

Keywords:
ChildrenEfficacyHenoch-Schönlein purpura nephritisSafetyTelitacicept

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Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Rheumatology

Background:

  • Henoch-Schönlein Purpura Nephritis (HSPN) is a common vasculitis affecting children, characterized by kidney inflammation.
  • Current treatments for HSPN often have limitations, necessitating the exploration of novel therapeutic agents.
  • Telitacicept (RC18) is an emerging biologic agent with potential immunomodulatory effects.

Purpose of the Study:

  • To evaluate the efficacy and safety of Telitacicept (RC18) in pediatric patients diagnosed with HSPN.
  • To assess the impact of Telitacicept on key clinical and laboratory markers of HSPN.
  • To explore the potential mechanisms of action of Telitacicept in HSPN treatment.

Main Methods:

  • A prospective, self-controlled study involving children with HSPN.
  • Treatment with Telitacicept (RC18) administered over a 1-4 month follow-up period.
  • Monitoring of 24-hour urine total protein (UTP), urinary red blood cell (RBC) count, renal function, and safety parameters.

    • Main Results:

    • Telitacicept demonstrated a 100% response rate for 24-hour UTP and a 66.7% response rate for urine RBC count.
    • Significant reductions in 24-hour UTP and urinary RBC count were observed post-treatment (P<0.01).
    • Renal function remained stable, and no serious adverse reactions were reported, though minor biochemical and injection site reactions occurred.

    Conclusions:

    • Telitacicept (RC18) is effective in reducing proteinuria and hematuria in children with HSPN.
    • The treatment shows a favorable safety profile, making it a promising option for pediatric HSPN.
    • Preliminary findings suggest Telitacicept may modulate lymphocyte populations and Gd-IgA1 levels in HSPN.