Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

415
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
415
Erikson's Theory on Socioemotional Development during Childhood01:28

Erikson's Theory on Socioemotional Development during Childhood

1.0K
Erik Erikson, a stage theorist, adapted Freud's theory to emphasize social factors in personality development throughout life, a concept known as psychosocial development. Unlike Freud, who focused on early childhood, Erikson believed that personality evolves across eight life stages, each marked by a specific challenge or "crisis." Successful resolution of each stage fosters competence, while failure may lead to feelings of inadequacy.
The first four of Erikson's eight...
1.0K
Piaget's Theory of Cognitive Development from Childhood into Adulthood01:25

Piaget's Theory of Cognitive Development from Childhood into Adulthood

1.5K
Jean Piaget's theory of cognitive development emphasizes the role of thinking in a child's learning process, suggesting that children are naturally curious about their environment. His approach to development is discontinuous, proposing that cognitive abilities progress through distinct stages, each with unique characteristics. Central to Piaget's theory is schemata—mental structures that allow individuals to understand and interpret the world.
Schemata: Building Blocks of Knowledge
1.5K
Control System Problem01:21

Control System Problem

415
In an open-loop system, such as a basic thermostat, the poles of the transfer function influence the system's response but do not determine its stability. However, when feedback is introduced to form a closed-loop system, such as an advanced thermostat that adjusts heating based on room temperature, stability is governed by the new poles of the closed-loop transfer function.
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
415
Combinatorial Gene Control02:33

Combinatorial Gene Control

9.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.5K
Control Systems01:10

Control Systems

1.8K
Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preservation and reconstruction of vesicourethral support during laparoscopic radical prostatectomy accelerates early recovery of urinary continence: a retrospective cohort study.

Cancer treatment and research communications·2026
Same author

Mapping the global research landscape of macrophage extracellular traps: An analysis and synthesis of mechanisms, roles in disease, and therapeutic insights.

International immunopharmacology·2026
Same author

Resistance exercise alleviates overactive bladder by attenuating detrusor oxidative stress via peroxynitrite reduction.

European journal of medical research·2026
Same author

Mobile Phone Addiction and Suicidal Behaviors in Adolescents: School-Based Cross-Sectional Study in Zhejiang Province, China.

Journal of medical Internet research·2025
Same author

Trends and age-period-cohort effect on incidence and mortality of unintentional drowning from 1990 to 2021 in China.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2025
Same author

Associations among personality traits, emotional states, and self-management behaviors with quality of life in type 2 diabetes: a structural equation modeling approach examining emotional mediation.

Frontiers in psychology·2025

Related Experiment Video

Updated: Jan 23, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.7K

Telitacicept for childhood HSPN: A prospective self-controlled study.

Hanhan Zhang1, Dan Song2, Ke Song1

  • 1Pediatric Nephrology and Purpura Center, Children's Hospital, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, 450000, China.

Clinical Rheumatology
|January 22, 2026
PubMed
Summary

Telitacicept (RC18) effectively treats Henoch-Schönlein Purpura Nephritis (HSPN) in children by reducing urine protein and red blood cells. This study confirms its good clinical effects and safety profile for pediatric HSPN management.

Keywords:
ChildrenEfficacyHenoch-Schönlein purpura nephritisSafetyTelitacicept

More Related Videos

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
06:35

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm

Published on: April 28, 2016

35.0K
Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.5K

Related Experiment Videos

Last Updated: Jan 23, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.7K
Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
06:35

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm

Published on: April 28, 2016

35.0K
Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.5K

Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Rheumatology

Background:

  • Henoch-Schönlein Purpura Nephritis (HSPN) is a common vasculitis affecting children, characterized by kidney inflammation.
  • Current treatments for HSPN often have limitations, necessitating the exploration of novel therapeutic agents.
  • Telitacicept (RC18) is an emerging biologic agent with potential immunomodulatory effects.

Purpose of the Study:

  • To evaluate the efficacy and safety of Telitacicept (RC18) in pediatric patients diagnosed with HSPN.
  • To assess the impact of Telitacicept on key clinical and laboratory markers of HSPN.
  • To explore the potential mechanisms of action of Telitacicept in HSPN treatment.

Main Methods:

  • A prospective, self-controlled study involving children with HSPN.
  • Treatment with Telitacicept (RC18) administered over a 1-4 month follow-up period.
  • Monitoring of 24-hour urine total protein (UTP), urinary red blood cell (RBC) count, renal function, and safety parameters.

Main Results:

  • Telitacicept demonstrated a 100% response rate for 24-hour UTP and a 66.7% response rate for urine RBC count.
  • Significant reductions in 24-hour UTP and urinary RBC count were observed post-treatment (P<0.01).
  • Renal function remained stable, and no serious adverse reactions were reported, though minor biochemical and injection site reactions occurred.

Conclusions:

  • Telitacicept (RC18) is effective in reducing proteinuria and hematuria in children with HSPN.
  • The treatment shows a favorable safety profile, making it a promising option for pediatric HSPN.
  • Preliminary findings suggest Telitacicept may modulate lymphocyte populations and Gd-IgA1 levels in HSPN.