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Telitacicept for childhood HSPN: A prospective self-controlled study

Hanhan Zhang1, Dan Song2, Ke Song1

  • 1Pediatric Nephrology and Purpura Center, Children's Hospital, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, 450000, China.

Clinical Rheumatology
|January 22, 2026
PubMed

Insights

Telitacicept (RC18) effectively treats Henoch-Schönlein Purpura Nephritis (HSPN) in children by reducing urine protein and red blood cells. This study confirms its good clinical effects and safety profile for pediatric HSPN management.

Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Rheumatology

Background:

  • Henoch-Schönlein Purpura Nephritis (HSPN) is a common vasculitis affecting children, characterized by kidney inflammation.
  • Current treatments for HSPN often have limitations, necessitating the exploration of novel therapeutic agents.
  • Telitacicept (RC18) is an emerging biologic agent with potential immunomodulatory effects.

Purpose of the Study:

  • To evaluate the efficacy and safety of Telitacicept (RC18) in pediatric patients diagnosed with HSPN.
  • To assess the impact of Telitacicept on key clinical and laboratory markers of HSPN.
  • To explore the potential mechanisms of action of Telitacicept in HSPN treatment.

Main Methods:

  • A prospective, self-controlled study involving children with HSPN.
  • Treatment with Telitacicept (RC18) administered over a 1-4 month follow-up period.
  • Monitoring of 24-hour urine total protein (UTP), urinary red blood cell (RBC) count, renal function, and safety parameters.

Main Results:

  • Telitacicept demonstrated a 100% response rate for 24-hour UTP and a 66.7% response rate for urine RBC count.
  • Significant reductions in 24-hour UTP and urinary RBC count were observed post-treatment (P<0.01).
  • Renal function remained stable, and no serious adverse reactions were reported, though minor biochemical and injection site reactions occurred.

Conclusions:

  • Telitacicept (RC18) is effective in reducing proteinuria and hematuria in children with HSPN.
  • The treatment shows a favorable safety profile, making it a promising option for pediatric HSPN.
  • Preliminary findings suggest Telitacicept may modulate lymphocyte populations and Gd-IgA1 levels in HSPN.
Abstract

Keywords:
ChildrenEfficacyHenoch-Schönlein purpura nephritisSafetyTelitacicept

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