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  1. Home
  2. Quantifying The Risks: A Systematic Review And Proportional Meta-analysis Of The Perioperative Complications Of Posterior Cranial Vault Distraction Osteogenesis In Patients With Craniosynostosis.
  1. Home
  2. Quantifying The Risks: A Systematic Review And Proportional Meta-analysis Of The Perioperative Complications Of Posterior Cranial Vault Distraction Osteogenesis In Patients With Craniosynostosis.

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A Mouse Distraction Osteogenesis Model
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A Mouse Distraction Osteogenesis Model

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Quantifying the risks: a systematic review and proportional meta-analysis of the perioperative complications of

Mohammed A Fouda1, Thomas A Imahiyerobo1,2, Caitlin E Hoffman1

  • 11Department of Neurological Surgery, NewYork-Presbyterian Hospital, Weill Cornell Medicine, New York; and.

Journal of Neurosurgery. Pediatrics
|January 22, 2026

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
PCVDOcomplicationscongenitalcranial distractioncraniofacialcraniosynostosisposterior cranial vault distraction osteogenesissyndromic

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Posterior cranial vault distraction osteogenesis (PCVDO) in children has a 26.3% complication rate. Younger age and shorter latency periods increase risks for CSF leakage and reoperation.

Area of Science:

  • Neurosurgery
  • Pediatric Surgery
  • Craniofacial Surgery

Background:

  • Posterior cranial vault distraction osteogenesis (PCVDO) is a surgical technique to correct cranial deformities in children with craniosynostosis.
  • PCVDO increases intracranial volume but carries risks of perioperative complications.

Purpose of the Study:

  • To estimate the pooled prevalence of complications following PCVDO.
  • To identify factors influencing complication rates in pediatric craniosynostosis surgery.

Main Methods:

  • Systematic review and proportional meta-analysis following PRISMA guidelines.
  • Analysis of 33 English-language studies published between 2009 and 2025.
  • Quality assessment using the Newcastle-Ottawa Scale.

Main Results:

  • The overall complication rate for PCVDO was 26.3%.
  • Common complications included infection (10.4%), CSF leakage (6.7%), and device-related issues (6.0%).
  • Younger age and shorter latency periods were linked to increased risks of CSF leakage and reoperation.

Conclusions:

  • PCVDO is effective but has significant complication risks.
  • Patient age and latency period are key predictors of adverse outcomes.
  • Further innovations in device design and surgical protocols are needed to enhance safety.