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Updated: Jan 24, 2026

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb
Published on: August 30, 2016
People With Marfan Syndrome Utilize an Ankle Dominant Strategy to Perform the Sit-to-Stand Task
Justin M Pol1,2, Mariana V Jacobs3, Christopher J McLouth4
1Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA.
Abstract:
Marfan syndrome (MFS) is a connective tissue disorder caused by structural changes in fibrillin-1 and is associated with muscle weakness and joint pain. The understanding of lower extremity (LE) joint mechanics associated with joint pain in people with MFS is limited. The goal of this study was to assess LE joint mechanics during the sit-to-stand (STS) task in people with MFS compared with asymptomatic controls. Sixteen people with MFS and 16 sex- and body mass index-matched controls were tested in this study. All participants performed the STS task at a self-selected speed. Peak LE joint extensor moments, moment impulses, moment durations, time to task completion, total support moment (TSM), and each joint's contribution to the TSM were evaluated. People with MFS took longer to perform the task and exhibited lower peak knee extensor moments and higher peak ankle plantar flexor moments compared with controls. Higher LE joint extensor moments impulses and moment durations were observed in people with MFS. People with MFS performed the STS task using a higher TSM with higher ankle contributions to the TSM. People with MFS exhibit altered LE joint mechanics during the STS task and utilize a more ankle joint dominant strategy.
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