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Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
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Engineered Supramolecular Therapeutics in Development for Combating Antibiotic-Resistant Bacterial Infections.

Alex Odoom1, Abdul-Halim Osman2, Christian K O Dzuvor3

  • 1Department of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Korle-Bu, Accra GE-092-6238, Ghana.

ACS Applied Bio Materials
|January 22, 2026
PubMed
Summary

Antibiotic resistance necessitates novel antibacterial agents. Nanomaterials enhance nonantibiotic antimicrobials like antimicrobial peptides (AMPs) and bacteriophages (phages), improving efficacy and delivery for treating resistant infections.

Keywords:
antibiotic resistanceantimicrobial peptides (AMPs)bacteriophagesendolysinnanomaterialssupramolecular therapeutics

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Area of Science:

  • Nanoscience and Nanotechnology
  • Microbiology
  • Biotechnology

Background:

  • Antibiotic resistance poses a significant global health threat, rendering traditional treatments ineffective.
  • Novel antibacterial strategies are crucial, driving research into nonantibiotic agents.
  • Synthetic and bioengineered nanomaterials offer potential to enhance these agents.

Purpose of the Study:

  • To review the use of nanomaterials in augmenting nonantibiotic antibacterial agents.
  • To discuss strategies for overcoming limitations of these agents, such as cytotoxicity and poor bioavailability.
  • To highlight advancements in delivery systems and the role of AI in developing precision antimicrobials.

Main Methods:

  • Review of current literature on nanomaterial-enhanced nonantibiotic antibacterials.
  • Analysis of modifications and syntheses of agents like antimicrobial peptides (AMPs), metallic nanoparticles (MNPs), and bacteriophages (phages).
  • Exploration of supramolecular delivery strategies and the integration of artificial intelligence (AI) and machine learning (ML).

Main Results:

  • Nanomaterial integration significantly enhances the antibacterial properties of agents like AMPs, MNPs, and phages.
  • Advanced delivery systems, including phage-based and AMP-based supramolecular strategies, show efficacy against persistent infections.
  • AI and ML show promise in revolutionizing the design and optimization of precision antimicrobials.

Conclusions:

  • Nanomaterial-augmented nonantibiotic antibacterials represent a promising frontier against antibiotic resistance.
  • Improved delivery systems and AI-driven design are key to clinical translation.
  • These advancements pave the way for targeted and highly effective treatments for bacterial infections.