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  1. Home
  3. Recent Developments In Pediatric Respiratory Syncytial Virus Prevention: The Expanding Role Of Monoclonal Antibodies.
  1. Home
  3. Recent Developments In Pediatric Respiratory Syncytial Virus Prevention: The Expanding Role Of Monoclonal Antibodies.

Related Experiment Video

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
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Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus

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Recent developments in pediatric respiratory syncytial virus prevention: The expanding role of monoclonal antibodies.

Christine E Tabulov1, Kristy M Shaeer1

  • 1Department of Pharmacotherapeutics and Clinical Research, University of South Florida Taneja College of Pharmacy. Tampa, FL, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|January 22, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

New monoclonal antibodies offer improved protection against respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD) in infants and children. These advanced therapies, including nirsevimab and clesrovimab, are now preferred over older options like palivizumab.

Keywords:
infantmonoclonal antibodiesprophylaxisrespiratory syncytial virus

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Area of Science:

  • Pediatric Infectious Diseases
  • Immunology
  • Pharmacology

Background:

  • Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease (LRTD) in infants and young children.
  • Monoclonal antibodies have been developed for RSV prevention.
  • Palivizumab was the standard of care for many years.

Purpose of the Study:

  • To evaluate currently approved monoclonal antibodies for RSV LRTD prevention in pediatric populations.
  • To highlight key considerations for pharmacists regarding clinical decision-making, medication access, and patient education.

Main Methods:

  • Review of regulatory-approved monoclonal antibodies for RSV prevention.
  • Analysis of efficacy, safety, and administration profiles of newer agents.
  • Consideration of the evolving landscape of RSV therapeutics.

    • Main Results:

    • Nirsevimab and clesrovimab demonstrate strong efficacy and favorable safety profiles for preventing RSV LRTD.
    • These newer agents offer improved duration of protection and convenience compared to palivizumab.
    • Palivizumab is no longer the preferred preventative option.

    Conclusions:

    • Monoclonal antibodies are a critical strategy for preventing RSV LRTD in vulnerable pediatric groups.
    • Nirsevimab and clesrovimab represent significant advancements in RSV prevention.
    • Pharmacists are essential in optimizing the use of these therapies through patient selection, access navigation, and education.