Related Experiment Video

Updated: Jan 24, 2026

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

810

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation

Charly Kusch1, David Stegner1,2, Lukas J Weiss1,3

  • 1Institute of Experimental Biomedicine, Chair I, University Hospital Würzburg, Germany.

Science (New York, N.Y.)
|January 22, 2026
PubMed
Summary

Platelet integrin αIIbβ3 forms inflammatory structures called PITTs that worsen infections and thrombosis. Blocking αIIbβ3 may reduce immune damage and improve outcomes in severe diseases.

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